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Capek et al

Overwhelming evidence supports the notion that excessive intracellular zinc levels are implicated in the development of the disease

3.8 Effect of heterologous expression of Am ABCC1 and Am ABCC2 on xenobiotic tolerance in transgenic yeast To investigate any cytoprotective effect of these transporters towards xenobiotics and herbicides, Am ABCC1 and Am ABCC2 were expressed in Saccharomyces cerevisiae ycf1 strain defective in the cadmium factor protein, an ABCC transporter